The hormones in the urine are used to manufacture Hormone Replacement Therapy (HRT) products for women. The most commonly known drug produced with equine urine is Premarin®, now manufactured by pharmaceutical giant Pfizer (Pfizer purchased Wyeth Pharmaceuticals, the original manufacturer of the drug, in 2009).
Are all HRT made from horse urine?
Until relatively recently there were only a handful of HRT medicines available and two of those were made from pregnant mare’s urine. There are now a number of preparations, predominantly synthetic variations of human hormones, with a wide range of tablets, patches, gels and creams.
Is estradiol made from horse urine?
Estradiol: One product that is gaining new interest is estradiol, a synthetically produced copy of the estrogen that women’s ovaries make before menopause. While Prempro and Premarin are made from horse urine, estradiol more closely resembles the estrogen that a woman’s body naturally makes.
Is Premarin really made from horse urine?
The estrogen-replacement drug Premarin, prescribed to menopausal women, is made from horse urine; in fact, the drug’s name is short for PREgnant MARes’ urINe. About 750,000 mares are impregnated each year for the sole purpose of collecting their estrogen-rich urine.
Is vagifem made from horse urine?
Premarin and Vagifem are examples of vaginal E2 regimens. Premarin or conjugated equine estrogen (CEE) is a naturally occurring E2 derived from urine of mares. Conjugation enables the compound to be water-soluble and more absorbable (25). Premarin is also the third most common drug used in the U.S. (26).
Is HRT cruel to horses?
Both drugs contain horse urine, specifically pregnant mare’s urine (PMU). Not only has this form of HRT proved to be dangerous to humans, horses raised for their urine are also kept confined and pregnant, and their foals often end up in the slaughterhouse.
Is weight gain a side effect of Premarin?
Stomach upset, nausea/vomiting, bloating, breast tenderness, headache, or weight changes may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Tell your doctor promptly if you see the tablet in your stool.
What is the best alternative to Premarin?
What is the best alternative to Premarin? Estrace is a similar alternative to Premarin. Other medications containing estrogen include the Vivelle Dot Patch, Climara Patch, or vaginal estrogen in the form of Vagifem vaginal tablets (vaginal tablets applied with a vaginal applicator) or Estring Vaginal Ring.
What happens if I stop taking Premarin?
Stopping HRT may affect your bone health. The estrogen in HRT helps protect your bones by preventing bone loss, which can lead to osteoporosis. Once you stop taking estrogen, you may develop brittle bones.
Is there an alternative to estradiol?
1) Pellet hormone replacement is one alternative to Estradiol that works just as well, if not significantly better. 2) There are various other hormones that are in play when it comes to a hormone imbalance, and estrogen is only one of the many that may be causing problematical symptoms.
What are the risks of taking Premarin?
Common side effects of Premarin include:
- stomach upset or cramps,
- breast tenderness or swelling,
- weight or appetite changes,
- freckles or darkening of facial skin,
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How long should you take Premarin?
Your doctor will prescribe the dosage that’s right for you. Estrogens, with or without a progestin, should be used at the lowest effective dose for the shortest duration of time. A single tube of Premarin Vaginal Cream can last up to 6 months depending on the dose prescribed.
How long should you use Premarin cream?
A single tube of prescription Premarin Vaginal Cream can last up to 6 months depending on the dose prescribed. Estrogens should be used at the lowest effective dose, for the shortest duration consistent with treatment goals and risks for the individual woman.
Is vagifem safe for long term use?
Endometrial safety of long-term (more than one year) or repeated use of local vaginally administered oestrogen is uncertain. Therefore, if repeated, treatment should be reviewed at least annually, with special consideration given to any symptoms of endometrial hyperplasia or carcinoma.
Does lack of estrogen cause dementia?
There’s new evidence that a woman’s levels of female sex hormones, including estrogen and progesterone, can influence her risk of Alzheimer’s and other forms of dementia.
What’s the difference between Premarin and estradiol?
Estradiol is also used for comfort care in serious cases of breast cancer or prostate cancer. Premarin, on the other hand, is the brand name of a conjugated estrogen. Conjugated estrogen is also a medical formulation. It’s a mixture of several types of estrogens.